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PSYCHIATRIC GRAND ROUNDS
September 17, 2008

 

Title:

What Is Chronic Fatigue Syndrome? The Latest Research

Presenter:

Anthony L. Komaroff, M.D., The Simcox-Clifford-Higby Professor of Medicine, Harvard Medical School, Boston, MA

Location:

Hartford Room, The Commons Building, 2nd Floor, The Institute of Living/Hartford Hospital
200 Retreat Avenue, Hartford, CT 06106

Abstract:

Although chronic fatigue syndrome is defined only by a group of subjective symptoms, research is finding objective abnormalities in the central and autonomic nervous system, the immune system, and energy metabolism.  In addition, infectious agents have been associated with the illness.  Yet the illness is accompanied in some cases by psychiatric disturbance, as well.  The talk will summarize the latest information on the biology and psychiatric consequences of this illness. 

Learning Objectives

The participants will be able to:

  • Distinguish chronic fatigue syndrome from the much more common causes of the complaint of fatigue, including depression and a host of “organic” illnesses.

  • Understand the biological underpinnings of the illness.

  • Learn what is known about treatment options.

References:

Komaroff AL.  The biology of chronic fatigue syndrome.  Am J Med 2000;108:169-71.

Komaroff AL.  Chronic fatigue syndrome.  In:  Rakel RE, ed.  Conn’s Current Therapy 2003.  Houston, TX: WB Saunders, 2003:119-23.


Bibliography prepared by the IOL Medical Library.  Call 545-7276 for information.

 

Books

Wessely S et al.  Chronic Fatigue and Its Syndromes.  Oxford University Press, 1998. WB 146 W515c.

 

Articles

<1>  Scheeres K et al.  Implementing cognitive behavioral therapy for chronic fatigue syndrome in a mental health center: a benchmarking evaluation.  Journal of Consulting & Clinical Psychology.  76(1):163-71, 2008 Feb.

<2>  Huibers MJ.  Wessely S.  The act of diagnosis: pros and cons of labelling chronic fatigue syndrome. [Review] [34 refs]  Psychological Medicine.  36(7):895-900, 2006 Jul.  (ELECTRONIC FULL TEXT)

<3>  Maes M et al.  Lower serum zinc in Chronic Fatigue Syndrome (CFS): relationships to immune dysfunctions and relevance for the oxidative stress status in CFS.  Journal of Affective Disorders.  90(2-3):141-7, 2006 Feb.

<4>  Bentler SE et al.  Prospective observational study of treatments for unexplained chronic fatigue.  Journal of Clinical Psychiatry.  66(5):625-32, 2005 May.

<5>  Fossey M et al.  Sleep quality and psychological adjustment in chronic fatigue syndrome.  Journal of Behavioral Medicine.  27(6):581-605, 2004 Dec.  (ELECTRONIC FULL TEXT)

<6>  Hatcher S.  House A.  Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case-control study.  Psychological Medicine.  33(7):1185-92, 2003 Oct.

<7>  Hartz AJ et al.  The effectiveness of citalopram for idiopathic chronic fatigue.  Journal of Clinical Psychiatry.  64(8):927-35, 2003 Aug.

<8>  Afari N.  Buchwald D.  Chronic fatigue syndrome: a review. [Review] [230 refs]  American Journal of Psychiatry.  160(2):221-36, 2003 Feb.

<9>  Garralda ME.  Rangel L.  Annotation: Chronic Fatigue Syndrome in children and adolescents. [Review] [50 refs]  Journal of Child Psychology & Psychiatry & Allied Disciplines.  43(2):169-76, 2002 Feb.

<10> Deale A et al.  Long-term outcome of cognitive behavior therapy versus relaxation therapy for chronic fatigue syndrome: a 5-year follow-up study.  American Journal of Psychiatry.  158(12):2038-42, 2001 Dec.

<11> Wessely S.  Chronic fatigue: symptom and syndrome. [Review] [45 refs]  Annals of Internal Medicine.  134(9 Pt 2):838-43, 2001 May 1.  (ELECTRONIC FULL TEXT)

<12> Moss-Morris R.  Petrie KJ.  Discriminating between chronic fatigue syndrome and depression: a cognitive analysis.  Psychological Medicine.  31(3):469-79, 2001 Apr.


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